My host does not use CPanel. Can I still use WP Empire Builder?

WP Empire Builder will still work, it's just that it cannot create directories, subdomains and addon domains automatically. Those would need to be done manually.

Any (sub-) domain you add should be mapped to the same folder where your main site is installed. This is not a default value so pay attention to setting it carefully.

For example, if WP Empire Builder is installed on a domain called EmpireBuilderDomain.com then every time a subdomain is mapped manually, it should be added like this:

subdomain.EmpireBuilderDomain.com

And not subdomain.SomeOtherDomain.com