Sometimes, you may get a blank screen or errors like:
This is a common issue with plugins not tested against WordPress multisite and it has nothing to do with WP Empire Builder.
Here's how to find the plugin causing the problem:
You deactivate all plugins on the main "mother" site and try accessing the network admin. If the network admin becomes available ( your-mother-site.com/wp-admin/network/ ), it confirms one of the plugins was failing, because those plugins active on the main site are also loaded during network admin initialization.
Then by reactivating plugins, one-by-one on the main site and testing network admin availability the plugin(s) causing the error could be isolated.